It blocks adenosine receptors in the brain, which in turn changes the levels of certain chemicals, such as GABA and dopamine. Also if you're taking 3-4 pills of naproxen over two days seems like a lot. Comprehensive alcohol & food interactions for Midol Extended Relief (naproxen). Ibuprofen reduces prostaglandins (the chemicals that trigger the contractions that cause the uterus lining to shed) whereas Tylenol doesn't. Nov 13, 2018 · Acetaminophen and alcohol can both affect your liver. Antihistamine So pretty much the Actaminophin/Caffeine should take care of the headache and Caffine/Antihistimine should take care of the bloating. If I had to take naproxen just to get through my period, I would be concerned. Learn the dangers and safer alternatives. How risky is it to mix the two? Oct 6, 2025 · Mixing alcohol and Midol can increase risks of side effects like drowsiness, liver strain, and bleeding. Find out how.

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